Protein Kinase-Dependent Pathway Dermal Fibroblasts Via a Mitogen-Activated Oncostatin M Stimulates the Growth of

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  • Hironobu Ihn
  • Kunihiko Tamaki
چکیده

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Oncostatin M stimulates the growth of dermal fibroblasts via a mitogen-activated protein kinase-dependent pathway.

Oncostatin M (OSM), a member of the hemopoietic cytokine family, has been implicated in the process of fibrosis and dermal wound healing. As a part of an ongoing study of the mechanisms of fibrosis and dermal wound healing, we have investigated the mechanism of the growth regulation of dermal fibroblasts by OSM. OSM stimulates the mitogenesis of dermal fibroblasts in a dose-dependent manner. Th...

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تاریخ انتشار 2000